What are CAR T cells, in what diseases are they utilized, and what are the common toxicities of CAR T cells? Dr. Connor Johnson, MD, an oncologist at Massachusetts General Hospital, discusses chimeric antigen receptor cell therapy (CAR T) with a particular focus on lymphoma. The logistics of CAR T-cell therapy are described and toxicities are identified, including cytokine release syndrome (CRS), ICANS, and cytopenias.